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Degradation of pharmaceutical antibiotic (ciprofloxacin) by photocatalysis process using sol-gel based titanium dioxide nanoparticles

  • Nitesh Parmar ORCID logo EMAIL logo and Jitendra Kumar Srivastava

Abstract

This study is an attempt to the removal of Ciprofloxacin (CIP) antibiotic from simulated wastewater using a photocatalytic process. The photocatalytic process was carried out in a photocatalytic reactor in the presence of TiO2 nanoparticles. TiO2 nanoparticles were successfully prepared in a laboratory scale using sol-gel method with titanium-isopropoxide (TTIP) as titanium precursor. Prepared material was found very effective to the removal of CIP antibiotic. The maximum removal efficiency of 87.95% of ciprofloxacin from aqueous solution was achieved at the pH 5, catalyst doze of 40 mg L−1 with initial concentration of ciprofloxacin 5 mg L−1, and the reaction time of 100 min additionally; material characterization of TiO2 was presented in detail in terms of XRD, SEM, UV, and FTIR. It has been found that at the optimum condition the total operating cost indicated for the removal of ciprofloxacin from aqueous solution is 786.56 (INR/kg of CIP removal). This technique demonstrated that photocatalytic reaction in presence of TiO2 nanoparticles is well applicable to treat pharmaceutical wastewater.


Corresponding author: Nitesh Parmar, Department of Chemical Engineering, Ujjain Engineering College, Ujjain, Madhya Pradesh, India, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

Abhang, R. M., D. Kumar, and S. V. Taralkar. 2011. “Design of Photocatalytic Reactor for Degradation of Phenol in Wastewater.” International Journal of Chemical Engineering and Applications 2 (5): 337, https://doi.org/10.7763/ijcea.2011.v2.130.Search in Google Scholar

Al-Taweel, S. S., and H. R. Saud. 2016. “New Route for Synthesis of Pure Anatase TiO2 Nanoparticles via Ultrasound Assisted Sol-Gel Method.” Journal of Chemical and Pharmaceutical Research 8 (2): 620–6.Search in Google Scholar

Ali, T., P. Tripathi, A. Azam, W. Raza, A. S. Ahmed, A. Ahmed, and M. Muneer. 2017. “Photocatalytic Performance of Fe-Doped TiO2 Nanoparticles under Visible-Light Irradiation.” Materials Research Express 4: 015022, https://doi.org/10.1088/2053-1591/aa576d.Search in Google Scholar

An, T., H. Yang, G. Li, W. Song, W.J. Cooper, and X. Nie. 2010. “Kinetics and mechanism of advanced oxidation processes (AOPs) in degradation of ciprofloxacin in water.” Applied Catalysis B: Environmental 94 (3–4): 288–294.10.1016/j.apcatb.2009.12.002Search in Google Scholar

Asha, R. C., M. A. Vishnuganth, N. Remya, N. Selvaraju, and M. Kumar. 2015. “Livestock Wastewater Treatment in Batch and Continuous Photocatalytic Systems: Performance and Economic Analyses.” Water, Air, & Soil Pollution 226 (5): 1–13, https://doi.org/10.1007/s11270-015-2396-4.Search in Google Scholar

Balarak, D., and H. Azarpira. 2016. “Photocatalytic Degradation of Sulfamethoxazole in Water: Investigation of the Effect of Operational Parameters.” International Journal of ChemTech Research 9 (12): 731–8, https://doi.org/10.21786/bbrc/9.3/32.Search in Google Scholar

Basturk, F. B., M. H. Nekoofar, M. Gunday, and P. M. H. Dummer. 2018. “X-ray Diffraction Analysis of MTA Mixed and Placed with Various Techniques.” Clinical Oral Investigations 22: 1675–80, https://doi.org/10.1007/s00784-017-2241-9.Search in Google Scholar PubMed

Bohdziewicz, J., E. Kudlek, and M. Dudziak. 2016. “Influence of the catalyst type (TiO2 and ZnO) on the photocatalytic oxidation of pharmaceuticals in the aquatic environment.” Desalination and water treatment 57 (3): 1552–1563.10.1080/19443994.2014.988411Search in Google Scholar

Bouyarmane, H., C. El Bekkali, J. Labrag, I. Es-saidi, O. Bouhnik, H. Abdelmoumen, A. Laghzizil, J. M. Nunzi, and D. Robert. 2021. “Photocatalytic Degradation of Emerging Antibiotic Pollutants in Waters by TiO2/Hydroxyapatite Nanocomposite Materials.” Surfaces and Interfaces 24: 101155, https://doi.org/10.1016/j.surfin.2021.101155.Search in Google Scholar

Davari, N., M. Farhadian, and A.R. Solaimany Nazar. 2021. “Synthesis and characterization of Fe2O3 doped ZnO supported on clinoptilolite for photocatalytic degradation of metronidazole.” Environmental technology 42 (11): 1734–1746.10.1080/09593330.2019.1680738Search in Google Scholar PubMed

Dimitrakopoulou, D., I. Rethemiotaki, Z. Frontistis, N. P. Xekoukoulotakis, D. Venieri, and D. Mantzavinos. 2012. “Degradation, Mineralization and Antibiotic Inactivation of Amoxicillin by UV-A/TiO2 Photocatalysis.” Journal of Environmental Management 98: 168–74, https://doi.org/10.1016/j.jenvman.2012.01.010.Search in Google Scholar PubMed

Elbushra, H., M. Ahmed, H. Wardi, and N. Eassa. 2018. “Synthesis and Characterization of TiO 2 Using Sol-Gel Method at Different Annealing Temperatures.” MRS Advances 3 (42): 2527–35, https://doi.org/10.1557/adv.2018.230.Search in Google Scholar

Farzadkia, M., A. Esrafili, M.A. Baghapour, Y.D. Shahamat, and N. Okhovat. 2014. “Degradation of metronidazole in aqueous solution by nano-ZnO/UV photocatalytic process.” Desalination and Water Treatment 52 (25–27): 4947–4952.10.1080/19443994.2013.810322Search in Google Scholar

Fries, E., C. Crouzet, C. Michel, and A. Togola. 2016. “Interactions of ciprofloxacin (CIP), titanium dioxide (TiO2) nanoparticles and natural organic matter (NOM) in aqueous suspensions.” Science of The Total Environment 563: 971–976.10.1016/j.scitotenv.2015.12.023Search in Google Scholar PubMed

Gad-Allah, T. A., M. E. Ali, and M. I. Badawy. 2011. “Photocatalytic Oxidation of Ciprofloxacin under Simulated Sunlight.” Journal of Hazardous Materials 186 (1): 751–5, https://doi.org/10.1016/j.jhazmat.2010.11.066.Search in Google Scholar PubMed

Giraldo-Aguirre, A. L., E. A. Serna-Galvis, E. D. Erazo-Erazo, J. Silva-Agredo, H. Giraldo-Ospina, O. A. Flórez-Acosta, and R. A. Torres-Palma. 2018. “Removal of β-lactam Antibiotics from Pharmaceutical Wastewaters Using Photo-Fenton Process at Near-Neutral pH.” Environmental Science and Pollution Research 25 (21): 20293–303, https://doi.org/10.1007/s11356-017-8420-z.Search in Google Scholar PubMed

Hassani, A., A. Khataee, and S. Karaca. 2015. “Photocatalytic Degradation of Ciprofloxacin by Synthesized TiO2 Nanoparticles on Montmorillonite: Effect of Operation Parameters and Artificial Neural Network Modeling.” Journal of Molecular Catalysis A: Chemica l409: 149–61, https://doi.org/10.1016/j.molcata.2015.08.020.Search in Google Scholar

Hassani, A., A. Khataee, S. Karaca, and M. Fathinia. 2016. “Heterogeneous Photocatalytic Ozonation of Ciprofloxacin Using Synthesized Titanium Dioxide Nanoparticles on a Montmorillonite Support: Parametric Studies, Mechanistic Analysis and Intermediates Identification.” RSC Advances 6 (90): 87569–83, https://doi.org/10.1039/c6ra19191f.Search in Google Scholar

Ijadpanah-Saravy, H., M. Safari, A. Khodadadi-Darban, and A. Rezaei. 2014. “Synthesis of Titanium Dioxide Nanoparticles for Photocatalytic Degradation of Cyanide in Wastewater.” Analytical Letters 47 (10): 1772–82, https://doi.org/10.1080/00032719.2014.880170.Search in Google Scholar

Ilkhechi, N. N., F. Dousi, B. K. Kaleji, and E. Salahi. 2015. “Optical andStructural Properties of TiO2 Nanocomposite Doped by Si andCu at High Temperature.” Opticaland Quantum Electronics 47: 1751–63, https://doi.org/10.1007/s11082-014-0033-x.Search in Google Scholar

Khan, M.M., S.A. Ansari, D. Pradhan, M.O. Ansari, J. Lee, and M.H. Cho. 2014. “Band gap engineered TiO2 nanoparticles for visible light induced photoelectrochemical and photocatalytic studies.” Journal of Materials Chemistry A 2 (3): 637–644.10.1039/C3TA14052KSearch in Google Scholar

Khoshnamvand, N., S. Ahmadi, and F. K. Mostafapour. 2017. “Kinetic and Isotherm Studies on Ciprofloxacin an Adsorption Using Magnesium Oxide Nanoparticles.” Journal of Applied Pharmaceutical Science 7 (11): 079–83.Search in Google Scholar

Kulkarni, R.M., R.S. Malladi, M.S. Hanagadakar, M.R. Doddamani, and U.K. Bhat. 2016. “Ag-TiO2 nanoparticles for photocatalytic degradation of lomefloxacin.” Desalination and Water Treatment 57 (34): 16111–16118.10.1080/19443994.2015.1076352Search in Google Scholar

Liu, M., L. Zhang, B. D. Xi, S. Yu, X. Hu, and L. A. Hou. 2017. “Degradation of Ciprofloxacin by TiO 2/Fe 2 O 3/zeolite Catalyst-Activated Persulfate under Visible LED Light Irradiation.” RSC Advances 7 (81): 51512–20, https://doi.org/10.1039/c7ra08475g.Search in Google Scholar

Malakootian, M., A. Nasiri, and M. Amiri Gharaghani. 2020. “Photocatalytic Degradation of Ciprofloxacin Antibiotic by TiO2 Nanoparticles Immobilized on a Glass Plate.” Chemical Engineering Communications 207 (1): 56–72, https://doi.org/10.1080/00986445.2019.1573168.Search in Google Scholar

Manasa, M., P. R. Chandewar, and H. Mahalingam. 2020 In press. “Photocatalytic Degradation of Ciprofloxacin & Norfloxacin and Disinfection Studies under Solar Light Using Boron & Cerium Doped TiO2 Catalysts Synthesized by Green EDTA-Citrate Method.” Catalysis Today 375: 522–36, doi:https://doi.org/10.1016/j.cattod.2020.03.018.Search in Google Scholar

Mansoury, M. S., H. Godini, and G. S. Khorramabadi. 2015. “Photocatalytic Removal of Natural Organic Matter from Aqueous Solutions Using Zinc Oxide Nanoparticles Immobilized on Glass.” Iranian Journal of Health and Environment 8 (2): 181–90.Search in Google Scholar

Mushtaq, K., M. Saeed, W. Gul, M. Munir, A. Firdous, T. Yousaf, K. Khan, H. M. R. Sarwar, M. A. Riaz, and S. Zahid. 2020. “Synthesis and Characterization of TiO2 via Sol-Gel Method for Efficient Photocatalytic Degradation of Antibiotic Ofloxacin.” Inorganic and Nano-Metal Chemistry 50: 580–6, https://doi.org/10.1080/24701556.2020.1722695.Search in Google Scholar

Patterson, A.L., 1939. “The Scherrer formula for X-ray particle size determination”. Physical review 56(10):978.10.1103/PhysRev.56.978Search in Google Scholar

Rahimi, S., A. Poormohammadi, B. Salmani, M. Ahmadian, and M. Rezaei. 2016. “Comparing the Photocatalytic Process Efficiency Using Batch and Tubular Reactors in Removal of Methylene Blue Dye and COD from Simulated Textile Wastewater.” Journal of Water Reuse and Desalination 6 (4): 574–82, https://doi.org/10.2166/wrd.2016.190.Search in Google Scholar

Serna-Galvis, E. A., J. Silva-Agredo, A. L. Giraldo, O. A. Flórez, and R. A. Torres-Palma. 2016. “Comparison of Route, Mechanism and Extent of Treatment for the Degradation of a β-lactam Antibiotic by TiO2 Photocatalysis, Sonochemistry, Electrochemistry and the Photo-Fenton System.” Chemical Engineering Journal 284: 953–62, https://doi.org/10.1016/j.cej.2015.08.154.Search in Google Scholar

Scrimieri, L., L. Velardi, A. Serra, D. Manno, F. Ferrari, M. Cantarella, and L. Calcagnile. 2020. “Enhanced Adsorption Capacity of Porous Titanium Dioxide Nanoparticles Synthetized in Alkaline Sol.” Applied Physics A 126 (12): 1–8, https://doi.org/10.1007/s00339-020-04103-2.Search in Google Scholar

Shahrezaei, F., Y. Mansouri, A. A. L. Zinatizadeh, and A. Akhbari. 2012. “Photocatalytic Degradation of Aniline Using TiO2 Nanoparticles in a Vertical Circulating Photocatalytic Reactor.” International Journal of Photoenergy 2012: 8.10.1155/2012/430638Search in Google Scholar

Shokri, M., G. Isapour, M.A. Behnajady, and S. Dorosti. 2016. “A comparative study of photocatalytic degradation of the antibiotic cefazolin by suspended and immobilized TiO2 nanoparticles". Desalination and Water.” Treatment 57 (27): 12874–12881.10.1080/19443994.2015.1053534Search in Google Scholar

Spurr, R. A., and H. Myers. 1957. “Quantitative Analysis of Anatase-Rutile Mixtures with an X-Ray Diffractometer.” Analytical Chemistry 29 (5): 760–2, https://doi.org/10.1021/ac60125a006.Search in Google Scholar

Sridar, R., U.U. Ramanane, and M. Rajasimman. 2018. “ZnO nanoparticles–Synthesis, characterization and its application for phenol removal from synthetic and pharmaceutical industry wastewater.” Environmental nanotechnology, monitoring & management 10: 388–393.10.1016/j.enmm.2018.09.003Search in Google Scholar

Varma, K. S., V. G. Gandhi, R. J. Tayade, A. D. Shukla, B. Bharatiya, and P. A. Joshi. 2021. “Photocatalytic Degradation of Levofloxacin by Cu Doped TiO2 under Visible LED Light.” Advances in Wastewater Treatment II 102: 182–98, https://doi.org/10.21741/9781644901397-7.Search in Google Scholar

Verma, A., I. Chhikara, and D. Dixit. 2014. “Photocatalytic Treatment of Pharmaceutical Industry Wastewater over TiO2 Using Immersion Well Reactor: Synergistic Effect Coupling with Ultrasound.” Desalination and Water Treatment 52 (34–36): 6591–7, https://doi.org/10.1080/19443994.2013.822164.Search in Google Scholar

Verma, M., and A. K. Haritash. 2020. “Photocatalytic Degradation of Amoxicillin in Pharmaceutical Wastewater: A Potential Tool to Manage Residual Antibiotics.” Environmental Technology & Innovation 20: 101072, https://doi.org/10.1016/j.eti.2020.101072.Search in Google Scholar

Wang, J., L. Svoboda, Z. Němečková, M. Sgarzi, J. Henych, N. Licciardello, and G. Cuniberti. 2021. “Enhanced Visible-Light Photodegradation of Fluoroquinolone-Based Antibiotics and E. coli Growth Inhibition Using Ag–TiO2 Nanoparticles.” RSC Advances 11 (23): 13980–91, https://doi.org/10.1039/d0ra10403e.Search in Google Scholar PubMed PubMed Central

Received: 2021-04-18
Accepted: 2021-07-25
Published Online: 2021-08-09

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